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Research Article

Development of QCM Sensor Based on Thiolated βCD for Sensing 2-Nonenal

2-Nonenal 감지용 싸이올화 된 βcyclodextrin 기반 QCM 센서의 개발

Min-Seok Oh1, Seong-ho Choi2

오민석1, 최성호2

1PhD, Hannam University
2Professor, Hannam University
1한남대학교 박사과정
2한남대학교 교수
30 September 2023. pp. 13-25
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Abstract
인체의 체취는 다양한 성분으로 구성되어 있다. 노인냄새의 대표적인 물질인 2-노네날은 피부 분비물의 산화에 의해 발생한다. 2-노네날을 정량화하기 위해서는 가스크로마토그래피-질량분석기(GC-MS)를 악취분석기로 사용할 수 있으나 비용이 매우 비싸고 측정시간이 길며 악취를 직접 샘플링하기 때문에 어렵다. 반면 QCM(Quartz Crystal Microbalance) 센서는 낮은 비용 및 즉시적으로 냄새를 감지하는데 쉽게 사용할 수 있다. 2-nonenal을 감지하기 위해 QCM 센서에서 호스트 화합물로 βCD를 도입했다. QCM 표면에서 이를 변형하기 위해, βCD의 모든 1차 하이드록시 그룹으로부터 싸이올 그룹으로의 치환 반응에 의해 티올화 βCD(βCD-SH)를 합성하였다. 합성된 βCD-SH는 자체 조립에 의해 싸이올화된 알킬 사슬과 금 나노입자로 QCM 표면에 게질되었다. 2-노네날 용액의 농도에 따른 2-노네날 측정을 하였다. 또한, 측정된 데이터의 신뢰도를 GC-MS 데이터와 비교하였다. 마지막으로, Sauerbrey 방정식에 의해 βCD-SH와 2-nonenal 사이의 포함 특성을 계산하였다.
Human body odor consists of various components. 2-Nonenal which is representative material of senior odor is occurred by oxidation of skin secretion. In order to quantify 2-nonenal, gas chromatography-mass spectrometer (GC-MS) can be used as odor analyzer, but it is difficult because of very expensive cost, long measurement time, and sampling odor directly. On the other hand, quartz crystal microbalance (QCM) sensor can easily be used for sensing human body odor because of cheap cost, rapid response time and without sampling. For sensing 2-nonenal, we introduced βCD as host compound in QCM sensor. To modify it on QCM surface, thiolated βCD (βCD-SH) was synthesized by substitution reaction to thiol group from all primary hydroxy group of βCD. The synthesized βCD-SH was modified onto QCM surface with thiolated alkyl chain and gold nanoparticles by self-assembly. Measurement of 2-nonenal was carried out according to concentration of 2-nonenal solution. Also, reliability of measured data was compared with GC-MS data. Finally, we calculated inclusion properties between βCD-SH and 2-nonenal by Sauerbrey’s equation.
Keywords
Human body odor
2-noneral
Senior odor
Quartz crystal microbalance
β-Cyclo dextrin
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Information
  • Publisher :The Society of Convergence Knowledge
  • Publisher(Ko) :융복합지식학회
  • Journal Title :The Society of Convergence Knowledge Transactions
  • Journal Title(Ko) :융복합지식학회논문지
  • Volume : 11
  • No :3
  • Pages :13-25
  • DOI :https://doi.org/10.22716/sckt.2023.11.3.022
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